产品名称
N4BP3 Rabbit Polyclonal Antibody
蛋白名称
NEDD4-binding protein 3 (N4BP3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23138
Human Swissprot No.
O15049
Human Swissprot Link
https://www.uniprot.org/uniprot/O15049
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=212706
Mouse Swissprot No.
Q8C7U1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C7U1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100910276
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3LUD3/entry
特异性
This antibody detects endogenous levels of N4BP3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasmic vesicle . Cell projection, axon . Cell projection, dendrite . In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites. .
功能
Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 . Plays also a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity).
