产品名称
IL-17RE Rabbit Polyclonal Antibody
基因名称
IL17RE UNQ3056/PRO9877
蛋白名称
Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=132014
Human Swissprot No.
Q8NFR9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NFR9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57890
Mouse Swissprot No.
Q8BH06
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BH06/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362417
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AZ51/entry
特异性
This antibody detects endogenous levels of IL-17RE at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.
细胞定位
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Cytoplasm .; [Isoform 3]: Secreted .; [Isoform 4]: Cytoplasm .; [Isoform 5]: Secreted .
功能
Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.
