产品名称
RND2 Rabbit Polyclonal Antibody
蛋白名称
Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P52198
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P52198/entry
Mouse Swissprot No.
Q9QYM5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYM5
免疫原
Synthesized peptide derived from human protein . at AA range: 140-220
特异性
RND2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in testis.
细胞定位
Cytoplasmic vesicle, secretory vesicle, acrosome membrane ; Lipid-anchor ; Cytoplasmic side . Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. .
功能
function:May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome.,subunit:Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.,tissue specificity:Highly expressed in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
