产品名称
TRUB2 Rabbit Polyclonal Antibody
蛋白名称
Probable tRNA pseudouridine synthase 2 (EC 5.4.99.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26995
Human Swissprot No.
O95900
Human Swissprot Link
https://www.uniprot.org/uniprot/O95900
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=227682
Mouse Swissprot No.
Q91WG3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91WG3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=366012
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XFW2/entry
特异性
This antibody detects endogenous levels of TRUB2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion matrix . Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. .
功能
Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation . Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs .
