产品名称
ZBTB48 Rabbit Polyclonal Antibody
蛋白名称
Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (Protein HKR3) (Zinc finger protein 855)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3104
Human Swissprot No.
P10074
Human Swissprot Link
https://www.uniprot.org/uniprot/P10074
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100090
Mouse Swissprot No.
Q1H9T6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q1H9T6/entry
特异性
This antibody detects endogenous levels of ZBTB48 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in adrenal gland and neuroblastoma.
细胞定位
Nucleus . Chromosome, telomere . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257). .
功能
Telomere-binding protein that acts as a regulator of telomere length . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat . Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres . Also acts as a transcription regulator that binds to promoter regions . Regulates expression of a small subset of genes, including MTFP1 . Regulates expression the J and/or S elements in MHC II promoter . Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A .
