产品名称
SPIRE2 Rabbit Polyclonal Antibody
基因名称
SPIRE2 KIAA1832 SPIR2
蛋白名称
Protein spire homolog 2 (Spir-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84501
Human Swissprot No.
Q8WWL2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WWL2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=234857
Mouse Swissprot No.
Q8K1S6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K1S6/entry
特异性
This antibody detects endogenous levels of SPIRE2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. .
功能
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning and asymmetric cell division during meiosis . Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis . Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage .
