产品名称
SELK Rabbit Polyclonal Antibody
基因名称
SELK HSPC030 HSPC297
蛋白名称
Selenoprotein K (SelK)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58515
Human Swissprot No.
Q9Y6D0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y6D0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80795
Mouse Swissprot No.
Q9JLJ1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JLJ1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=290549
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P59798/entry
特异性
This antibody detects endogenous levels of SELK at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in heart.
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Cell membrane ; Single-pass membrane protein . Probably mainly localized in the ER. .
功能
Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins . Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function . Plays a role in protection of cells from ER stress-induced apoptosis . Protects cells from oxidative stress when overexpressed in cardiomyocytes .
