产品名称
RILPL1 Rabbit Polyclonal Antibody
蛋白名称
RILP-like protein 1 (Rab-interacting lysosomal-like protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=353116
Human Swissprot No.
Q5EBL4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5EBL4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75695
Mouse Swissprot No.
Q9JJC6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJC6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304469
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D3ZUQ0/entry
特异性
This antibody detects endogenous levels of RILPL1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed at lower level in liver and kidney.
细胞定位
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body .
功能
Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution . Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis .
