产品名称
MURC Rabbit Polyclonal Antibody
蛋白名称
Muscle-related coiled-coil protein (Muscle-restricted coiled-coil protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=347273
Human Swissprot No.
Q5BKX8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5BKX8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68016
Mouse Swissprot No.
A2AMM0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2AMM0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=313225
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B1PRL5/entry
特异性
This antibody detects endogenous levels of MURC at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, myofibril, sarcomere . Cytoplasm . Cytoplasm, cytosol . Cell membrane, sarcolemma . Membrane, caveola . Cell membrane . In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner. .
功能
Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway .
