产品名称
MSL1 Rabbit Polyclonal Antibody
蛋白名称
Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=339287
Human Swissprot No.
Q68DK7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q68DK7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74026
Mouse Swissprot No.
Q6PDM1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PDM1/entry
特异性
This antibody detects endogenous levels of MSL1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Nucleus, nucleoplasm . Nucleus speckle .
功能
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure . Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) . This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 . In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation .
