产品名称
KMT2C Rabbit Polyclonal Antibody
基因名称
MLL3 HALR KIAA1506 KMT2C
蛋白名称
Histone-lysine N-methyltransferase MLL3 (EC 2.1.1.43) (Homologous to ALR protein) (Lysine N-methyltransferase 2C) (KMT2C) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58508
Human Swissprot No.
Q8NEZ4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NEZ4
Mouse Swissprot No.
Q8BRH4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BRH4/entry
特异性
This antibody detects endogenous levels of KMT2C at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
功能
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) . Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place . Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements .
