产品名称
KCNIP2 Rabbit Polyclonal Antibody
蛋白名称
Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Cardiac voltage-gated potassium channel modulatory subunit) (Potassium channel-interacting protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30819
Human Swissprot No.
Q9NS61
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NS61
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80906
Mouse Swissprot No.
Q9JJ69
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ69/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100911951
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JM59/entry
特异性
This antibody detects endogenous levels of KCNIP2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
细胞定位
[Isoform 1]: Cell membrane ; Lipid-anchor . Detected on lipid rafts (By similarity). .; [Isoform 2]: Cell membrane ; Lipid-anchor .; [Isoform 6]: Cell membrane ; Lipid-anchor .
功能
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).
