产品名称
CCDC109B Rabbit Polyclonal Antibody
蛋白名称
Coiled-coil domain-containing protein 109B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55013
Human Swissprot No.
Q9NWR8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NWR8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66815
Mouse Swissprot No.
Q810S1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q810S1/entry
特异性
This antibody detects endogenous levels of CCDC109B at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion inner membrane ; Multi-pass membrane protein .
功能
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
