产品名称
SLC5A11 Rabbit Polyclonal Antibody
基因名称
SLC5A11 KST1 SLGTX SMIT2
蛋白名称
Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=115584
Human Swissprot No.
Q8WWX8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WWX8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233836
Mouse Swissprot No.
Q8K0E3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0E3/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1F2/entry
特异性
This antibody detects endogenous levels of SLC5A11 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
