产品名称
LRDD Rabbit Polyclonal Antibody
蛋白名称
p53-induced protein with a death domain (Leucine-rich repeat and death domain-containing protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55367
Human Swissprot No.
Q9HB75
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HB75
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57913
Mouse Swissprot No.
Q9ERV7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERV7/entry
特异性
This antibody detects endogenous levels of LRDD at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Enriched in the nucleus upon DNA damage. .
功能
Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis . Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis . Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B .
