产品名称
FBXO11 Rabbit Polyclonal Antibody
基因名称
FBXO11 FBX11 VIT1 UG063H01
蛋白名称
F-box only protein 11 (Vitiligo-associated protein 1) (VIT-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80204
Human Swissprot No.
Q86XK2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86XK2
Mouse Swissprot No.
Q7TPD1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TPD1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=301674
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TSL3/entry
特异性
This antibody detects endogenous levels of FBXO11 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
细胞定位
Nucleus. Chromosome.
功能
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
