产品名称
HKDC1 Rabbit Polyclonal Antibody
蛋白名称
Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80201
Human Swissprot No.
Q2TB90
Human Swissprot Link
https://www.uniprot.org/uniprot/Q2TB90
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=216019
Mouse Swissprot No.
Q91W97
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91W97/entry
特异性
This antibody detects endogenous levels of HKDC1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed (PubMed:27459389, PubMed:29401404). Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein level) (PubMed:29401404). Present at moderate level in the thyroid follicular epithelium (at protein level) (PubMed:29401404).
细胞定位
Mitochondrion membrane ; Peripheral membrane protein . The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion. .
功能
Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases . Has low glucose phosphorylating activity compared to other hexokinases . Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity).
