产品名称
SPIB Rabbit Polyclonal Antibody
蛋白名称
Transcription factor Spi-B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6689
Human Swissprot No.
Q01892
Human Swissprot Link
https://www.uniprot.org/uniprot/Q01892
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=272382
Mouse Swissprot No.
O35906
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35906/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=499146
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EBA3/entry
特异性
This antibody detects endogenous levels of SPIB at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver.
细胞定位
[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm .
功能
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
