产品名称
PPIL2 Rabbit Polyclonal Antibody
蛋白名称
Peptidyl-prolyl cis-trans isomerase-like 2 (PPIase) (EC 5.2.1.8) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Rotamase PPIL2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23759
Human Swissprot No.
Q13356
Human Swissprot Link
https://www.uniprot.org/uniprot/Q13356
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66053
Mouse Swissprot No.
Q9D787
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D787/entry
特异性
This antibody detects endogenous levels of PPIL2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.
细胞定位
Nucleus . May also localize to the cytoplasm and the cell membrane. .
功能
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation . May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance . Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity .
