产品名称
SCUBE3 Rabbit Polyclonal Antibody
蛋白名称
Signal peptide, CUB and EGF-like domain-containing protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=222663
Human Swissprot No.
Q8IX30
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IX30
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=268935
Mouse Swissprot No.
Q66PY1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q66PY1/entry
特异性
This antibody detects endogenous levels of SCUBE3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.
细胞定位
Secreted . Cell surface .
功能
Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors . It is required for ligand-induced recruitment of BMP receptors to lipid rafts (By similarity). Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
