产品名称
C6orf130 Rabbit Polyclonal Antibody
蛋白名称
O-acetyl-ADP-ribose deacetylase C6orf130 (EC 3.5.1.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=221443
Human Swissprot No.
Q9Y530
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y530
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=106821
Mouse Swissprot No.
Q8R5F3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R5F3/entry
特异性
This antibody detects endogenous levels of C6orf130 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleoplasm . Nucleus, nucleolus . Chromosome . Localizes both in the nucleoplasm and in the nucleolus (PubMed:29712969). Relocalizes to the nucleoplasm in response to DNA damage (PubMed:29712969). Recruited to DNA lesion regions following DNA damage (PubMed:23481255). .
功能
ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose . Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins . Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins . Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively .
