产品名称
RHG05 Rabbit Polyclonal Antibody
蛋白名称
Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13017
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13017/entry
Mouse Swissprot No.
P97393
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97393
免疫原
Synthesized peptide derived from human protein . at AA range: 280-360
特异性
RHG05 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Detected in skin fibroblasts (at protein level) (PubMed:8537347).
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Also membrane-associated in a fibrillar pattern that colocalizes with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin. .
信号通路
Focal adhesion;Leukocyte transendothelial migration;
功能
function:GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of p120GAP.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 4 FF domains.,subcellular location:Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.,tissue specificity:Expressed in kidney, brain, liver and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
