产品名称
COX4NB Rabbit Polyclonal Antibody
基因名称
EMC8 C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4
蛋白名称
ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10328
Human Swissprot No.
O43402
Human Swissprot Link
https://www.uniprot.org/uniprot/O43402
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18117
Mouse Swissprot No.
O70378
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70378/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361425
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5FVL2/entry
特异性
This antibody detects endogenous levels of COX4NB at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).
