产品名称
CWC22 Rabbit Polyclonal Antibody
蛋白名称
Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57703
Human Swissprot No.
Q9HCG8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HCG8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80744
Mouse Swissprot No.
Q8C5N3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C5N3/entry
特异性
This antibody detects endogenous levels of CWC22 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Nucleus speckle . Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins. .
功能
Required for pre-mRNA splicing as component of the spliceosome . Promotes exon-junction complex (EJC) assembly . Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.
