产品名称
ARD1A Rabbit Polyclonal Antibody
基因名称
NAA10 ARD1 ARD1A TE2
蛋白名称
N-alpha-acetyltransferase 10 (EC 2.3.1.-) (EC 2.3.1.88) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8260
Human Swissprot No.
P41227
Human Swissprot Link
https://www.uniprot.org/uniprot/P41227
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56292
Mouse Swissprot No.
Q9QY36
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QY36/entry
特异性
This antibody detects endogenous levels of ARD1A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Also present in the free cytosolic and cytoskeleton-bound polysomes. .
功能
Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity . Acetylates amino termini that are devoid of initiator methionine . The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation . Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration . Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development . Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX . Acetylates HIST1H4A . Acts as a negative regulator of sister chromatid cohesion during mitosis .
