产品名称
DCUN1D1 Rabbit Polyclonal Antibody
基因名称
DCUN1D1 DCUN1L1 RP42 SCCRO
蛋白名称
DCN1-like protein 1 (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54165
Human Swissprot No.
Q96GG9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96GG9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114893
Mouse Swissprot No.
Q9QZ73
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZ73/entry
特异性
This antibody detects endogenous levels of DCUN1D1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.
细胞定位
Nucleus . Cytoplasm . The ubiquitinated form is localized in the cytoplasm. .
功能
Part of an E3 ubiquitin ligase complex for neddylation . Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes . Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity . Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
