产品名称
ROM1 Rabbit Polyclonal Antibody
反应种属
Human,Mouse,Rat,C. parvum
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6094
Human Swissprot No.
Q03395
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q03395/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19881
Mouse Swissprot No.
P32958
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P32958
Rat Gene Link
https://www.uniprot.org/uniprot/309201
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PPM7
免疫原
Synthesized peptide derived from human ROM1 AA range: 163-213
特异性
This antibody detects endogenous levels of ROM1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008],
组织表达
Retina photoreceptors (at protein level) (PubMed:1610568, PubMed:8504299). In rim region of ROS disks (PubMed:1610568).
细胞定位
Photoreceptor inner segment membrane ; Multi-pass membrane protein . Photoreceptor outer segment membrane ; Multi-pass membrane protein .
功能
disease:Defects in ROM1 may cause retinitis pigmentosa (RP) [MIM:268000]; when associated with defects in PRPH2.,function:May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the PRPH2/ROM1 family.,subunit:Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could associate with this complex in rods.,tissue specificity:Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
