产品名称
GRIPAP1 Rabbit Polyclonal Antibody
蛋白名称
GRIP1-associated protein 1 (GRASP-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56850
Human Swissprot No.
Q4V328
Human Swissprot Link
https://www.uniprot.org/uniprot/Q4V328
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54645
Mouse Swissprot No.
Q8VD04
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VD04/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116493
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHZ4/entry
特异性
This antibody detects endogenous levels of GRIPAP1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Early endosome membrane ; Peripheral membrane protein . Recycling endosome membrane ; Peripheral membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Localizes to recycling endosomal tubules that are emanating from early endosomes. .
功能
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). ; [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
