产品名称
TPMT Rabbit Polyclonal Antibody
蛋白名称
Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7172
Human Swissprot No.
P51580
Human Swissprot Link
https://www.uniprot.org/uniprot/P51580
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22017
Mouse Swissprot No.
O55060
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O55060/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z0T0/entry
特异性
This antibody detects endogenous levels of TPMT at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor . TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.
