产品名称
RHG20 Rabbit Polyclonal Antibody
蛋白名称
Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9P2F6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P2F6/entry
Mouse Swissprot No.
Q6IFT4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6IFT4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6REY9
免疫原
Synthesized peptide derived from human protein . at AA range: 800-880
特异性
RHG20 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an activator of RHO-type GTPases, transducing a signal from RAP1 to RHO and impacting neurite outgrowth. [provided by RefSeq, Sep 2016],
组织表达
Expressed predominantly in the brain. Lower expression is found in lymph nodes.
功能
caution:The translocation involving this gene was originally published as t(X;11)(q13;23) (PubMed:15543602), but BRWD3 is localized to Xq21 and not to Xq13.,developmental stage:Low expression is found in fetal liver.,disease:A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.,function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Expressed predominantly in the brain. Lower expression is found in lymph nodes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
