产品名称
UACA Rabbit Polyclonal Antibody
蛋白名称
Uveal autoantigen with coiled-coil domains and ankyrin repeats
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55075
Human Swissprot No.
Q9BZF9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BZF9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72565
Mouse Swissprot No.
Q8CGB3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CGB3/entry
特异性
This antibody detects endogenous levels of UACA at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
细胞定位
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Expressed diffusely in cytoplasm.
功能
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). ; Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).
