产品名称
PAAF1 Rabbit Polyclonal Antibody
蛋白名称
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80227
Human Swissprot No.
Q9BRP4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BRP4
特异性
This antibody detects endogenous levels of PAAF1 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed, with highest levels in kidney, brain and testis.
功能
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.
