产品名称
LIN7C Rabbit Polyclonal Antibody
蛋白名称
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55327
Human Swissprot No.
Q9NUP9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NUP9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22343
Mouse Swissprot No.
O88952
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88952/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60442
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q792I0/entry
特异性
This antibody detects endogenous levels of LIN7C at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell membrane ; Peripheral membrane protein . Basolateral cell membrane ; Peripheral membrane protein . Cell junction . Cell junction, synapse, postsynaptic density membrane ; Peripheral membrane protein . Cell junction, tight junction . Mainly basolateral in renal epithelial cells. .
功能
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
