产品名称
RBBP6 Rabbit Polyclonal Antibody
基因名称
RBBP6 P2PR PACT RBQ1 My038
蛋白名称
E3 ubiquitin-protein ligase RBBP6 (EC 6.3.2.-) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7Z6E9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7Z6E9/entry
Mouse Swissprot No.
P97868
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97868
免疫原
Synthesized peptide derived from human protein . at AA range: 270-350
特异性
RBBP6 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
细胞定位
Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.
功能
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,sequence caution:Intron retention.,similarity:Contains 1 CCHC-type zinc finger.,similarity:Contains 1 DWNN domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Colocalizes with mitotic chromosomes.,subunit:Interacts with p53/TP53 and RB1.,tissue specificity:Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
