产品名称
PRG2 Rabbit Polyclonal Antibody
蛋白名称
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5553
Human Swissprot No.
P13727
Human Swissprot Link
https://www.uniprot.org/uniprot/P13727
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19074
Mouse Swissprot No.
Q61878
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61878/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58826
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63189/entry
特异性
This antibody detects endogenous levels of PRG2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
细胞定位
[Bone marrow proteoglycan]: Secreted. The proform is secreted.; [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
功能
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
