产品名称
PDE9A Rabbit Polyclonal Antibody
蛋白名称
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5152
Human Swissprot No.
O76083
Human Swissprot Link
https://www.uniprot.org/uniprot/O76083
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18585
Mouse Swissprot No.
O70628
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70628/entry
特异性
This antibody detects endogenous levels of PDE9A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood (PubMed:9624146). Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate (PubMed:12565835). In brain, present in the cortex, cerebellum, and subiculum (at protein level) (PubMed:22328573). In heart, primarily localizes to myocytes (PubMed:25799991).
细胞定位
[Isoform PDE9A1]: Cell projection, ruffle membrane . Cytoplasm, perinuclear region . Golgi apparatus . Endoplasmic reticulum . Cell membrane, sarcolemma .; [Isoform PDE9A2]: Cell projection, ruffle membrane . Cytoplasm, perinuclear region .; [Isoform PDE9A3]: Cytoplasm . Endoplasmic reticulum .; [Isoform PDE9A17]: Cytoplasm . Endoplasmic reticulum .
功能
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP . Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart . Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
