产品名称
KLHL18 Rabbit Polyclonal Antibody
基因名称
KLHL18 KIAA0795 OK/SW-cl.74
蛋白名称
Kelch-like protein 18
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23276
Human Swissprot No.
O94889
Human Swissprot Link
https://www.uniprot.org/uniprot/O94889
特异性
This antibody detects endogenous levels of KLHL18 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis . The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry . Regulates light-and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (By similarity). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (By similarity). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (By similarity).
