产品名称
IMPCT Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55364
Human Swissprot No.
Q9P2X3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P2X3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16210
Mouse Swissprot No.
O55091
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O55091
Rat Gene Link
https://www.uniprot.org/uniprot/497198
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5GFD9
免疫原
Synthesized peptide derived from human IMPCT AA range: 123-173
特异性
This antibody detects endogenous levels of IMPCT at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Widely expressed. Expressed at high level in brain.
功能
function:Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis.,miscellaneous:In contrast to the mouse or rabbit ortholog, the IMPACT locus is not imprinted in human.,similarity:Belongs to the IMPACT family.,similarity:Contains 1 RWD domain.,subunit:Interacts with GCN1/GCN1L1.,tissue specificity:Widely expressed. Expressed at high level in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
