产品名称
PIP4K2B Rabbit Polyclonal Antibody
蛋白名称
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8396
Human Swissprot No.
P78356
Human Swissprot Link
https://www.uniprot.org/uniprot/P78356
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=108083
Mouse Swissprot No.
Q80XI4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80XI4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89812
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88377/entry
特异性
This antibody detects endogenous levels of PIP4K2B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Nucleus . Cytoplasm . Associated with the plasma membrane and the endoplasmic reticulum. .
功能
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate . Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration . Its GTP-sensing activity is critical for metabolic adaptation . PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 .
