产品名称
FUT10 Rabbit Polyclonal Antibody
蛋白名称
Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84750
Human Swissprot No.
Q6P4F1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6P4F1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171167
Mouse Swissprot No.
Q5F2L2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5F2L2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=497619
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5F2L1/entry
特异性
This antibody detects endogenous levels of FUT10 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in lung, digestive tract, gall bladder, placenta, kidney, uterus and brain. Not detected in spleen, heart, muscle, liver and pancreas.
细胞定位
[Isoform 1]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein .; [Isoform 4]: Golgi apparatus . Lysosome .; [Isoform 5]: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein .
功能
Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation . Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity). ; [Isoform 1]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. ; [Isoform 4]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. ; [Isoform 5]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit.
