产品名称
CCDC25 Rabbit Polyclonal Antibody
蛋白名称
Coiled-coil domain-containing protein 25
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55246
Human Swissprot No.
Q86WR0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q86WR0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67179
Mouse Swissprot No.
Q78PG9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q78PG9/entry
特异性
This antibody detects endogenous levels of CCDC25 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell membrane ; Single-pass membrane protein . Endomembrane system . Localizes to cytoplasmic membrane in tumor cells. .
功能
Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility . NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation . Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells . Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells . In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells .
