产品名称
SHC4 Rabbit Polyclonal Antibody
基因名称
SHC4 SHCD UNQ6438/PRO21364
蛋白名称
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=399694
Human Swissprot No.
Q6S5L8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6S5L8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=271849
Mouse Swissprot No.
Q6S5L9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6S5L9/entry
特异性
This antibody detects endogenous levels of SHC4 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
细胞定位
Cell junction, synapse, postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction. .
功能
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
