产品名称
Calsyntenin-1 Rabbit Polyclonal Antibody
蛋白名称
Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22883
Human Swissprot No.
O94985
Human Swissprot Link
https://www.uniprot.org/uniprot/O94985
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65945
Mouse Swissprot No.
Q9EPL2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPL2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=313717
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6Q0N0/entry
特异性
This antibody detects endogenous levels of Calsyntenin-1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level).
细胞定位
Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane . Cell projection, neuron projection . Cell junction, synapse, postsynaptic cell membrane ; Single-pass type I membrane protein . Nucleus . Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. .
功能
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).
