产品名称
HSD17B7 Rabbit Polyclonal Antibody
基因名称
HSD17B7 UNQ2563/PRO6243
蛋白名称
3-keto-steroid reductase (EC 1.1.1.270) (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51478
Human Swissprot No.
P56937
Human Swissprot Link
https://www.uniprot.org/uniprot/P56937
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15490
Mouse Swissprot No.
O88736
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88736/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29540
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62904/entry
特异性
This antibody detects endogenous levels of HSD17B7 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. ; [Isoform 3]: Expressed in eye ciliary epithelial cells and neuroendocrine cells.
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein .
功能
Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis . Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) . Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol . Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation . Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase . ; [Isoform 3]: Does not have enzymatic activities toward E1 and DHT.
