产品名称
PPP6C Rabbit Polyclonal Antibody
蛋白名称
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5537
Human Swissprot No.
O00743
Human Swissprot Link
https://www.uniprot.org/uniprot/O00743
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67857
Mouse Swissprot No.
Q9CQR6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQR6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171121
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q64620/entry
特异性
This antibody detects endogenous levels of PPP6C at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
细胞定位
Mitochondrion . Cytoplasm .
功能
Catalytic subunit of protein phosphatase 6 (PP6) . PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation . N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 . During mitosis, regulates spindle positioning . Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 . Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation . Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 . CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it .
