BD-PN1201

RGS17 Rabbit Polyclonal Antibody

常规抗体

RGS17

Regulator of G-protein signaling 17 (RGS17)

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

26575

Q9UGC6

https://www.uniprot.org/uniprotkb/Q9UGC6/entry

Q9QZB0

http://www.uniprot.org/uniprot/Q9QZB0

Synthesized peptide derived from human protein . at AA range: 70-150

RGS17 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

23kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008],

Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes.

Membrane . Cell junction, synapse, synaptosome . Nucleus . Cytoplasm .

function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,PTM:N- and O-glycosylated in synapsomal membranes.,PTM:Serine phosphorylated in synapsomal membranes.,PTM:Sumoylated by SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.,similarity:Contains 1 RGS domain.,subcellular location:Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.,tissue specificity:Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues noatably spleen, lung and leukocytes.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.