产品名称
CNOT8 Rabbit Polyclonal Antibody
蛋白名称
CCR4-NOT transcription complex subunit 8 (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9337
Human Swissprot No.
Q9UFF9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UFF9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=69125
Mouse Swissprot No.
Q9D8X5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D8X5/entry
特异性
This antibody detects endogenous levels of CNOT8 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus .
功能
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
