产品名称
DCUN1D5 Rabbit Polyclonal Antibody
蛋白名称
DCN1-like protein 5 (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84259
Human Swissprot No.
Q9BTE7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BTE7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76863
Mouse Swissprot No.
Q9CXV9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CXV9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315405
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PPL2/entry
特异性
This antibody detects endogenous levels of DCUN1D5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Weakly expressed in testis, skin and immune tissues (thymus, spleen and lymph nodes).
细胞定位
Nucleus . Cytoplasm, cytoskeleton, spindle . Subcellular localization is independent of the interaction with cullins. .
功能
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) . May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth .
