产品名称
PTBP2 Rabbit Polyclonal Antibody
基因名称
PTBP2 NPTB PTB PTBLP
蛋白名称
Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58155
Human Swissprot No.
Q9UKA9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UKA9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56195
Mouse Swissprot No.
Q91Z31
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Z31/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=310820
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q66H20/entry
特异性
This antibody detects endogenous levels of PTBP2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.
功能
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. ; [Isoform 5]: Reduced affinity for RNA.
