产品名称
SLC19A1 Rabbit Polyclonal Antibody
蛋白名称
Folate transporter 1 (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (Solute carrier family 19 member 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6573
Human Swissprot No.
P41440
Human Swissprot Link
https://www.uniprot.org/uniprot/P41440
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20509
Mouse Swissprot No.
P41438
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P41438/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62866/entry
特异性
This antibody detects endogenous levels of SLC19A1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Placenta, liver, and to a much smaller extent, in lung.
细胞定位
Cell membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .
功能
Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides . Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate . Also able to mediate the import of antifolate drug methotrexate . Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP . Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates . 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity .
